Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 461)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0410073	0.0998205	0.6853737
Weighted median	23	-0.0254318	0.0552999	0.6455957
Inverse variance weighted	23	-0.0093723	0.0390157	0.8101608
Simple mode	23	-0.0146267	0.0932017	0.8767266
Weighted mode	23	-0.0122103	0.0708725	0.8647877

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.77292	21	0.8341714
Inverse variance weighted	14.89147	22	0.8668535

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019427	0.0056423	0.7340389

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000453	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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