Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 460)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0118502	0.1018291	0.9084621
Weighted median	23	-0.0018819	0.0560524	0.9732169
Inverse variance weighted	23	-0.0289958	0.0390611	0.4578935
Simple mode	23	0.0782622	0.0897118	0.3924266
Weighted mode	23	0.0054263	0.0625171	0.9316174

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.85385	21	0.4079735
Inverse variance weighted	22.05149	22	0.4568191

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025083	0.0057558	0.6674357

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000685	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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