Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 46)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1145253	0.1170146	0.3388565
Weighted median	23	-0.0750546	0.0590552	0.2037561
Inverse variance weighted	23	-0.0435371	0.0451441	0.3348439
Simple mode	23	-0.0540807	0.0967809	0.5819449
Weighted mode	23	-0.0754699	0.0666969	0.2700135

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.85802	21	0.1174520
Inverse variance weighted	29.45497	22	0.1323239

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043594	0.0066143	0.5170003

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009302	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8