Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 459)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0538203	0.1027687	0.6059685
Weighted median	23	0.0156837	0.0611668	0.7976353
Inverse variance weighted	23	-0.0190395	0.0393704	0.6286705
Simple mode	23	-0.0067885	0.1064630	0.9497338
Weighted mode	23	0.0258551	0.0761315	0.7373704

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.25927	21	0.3847034
Inverse variance weighted	22.40257	22	0.4360912

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021359	0.005809	0.716787

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000686	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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