Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 458)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0300878	0.0998204	0.7660589
Weighted median	23	-0.0324712	0.0551557	0.5560499
Inverse variance weighted	23	-0.0387843	0.0390157	0.3201888
Simple mode	23	-0.1458741	0.0997840	0.1579073
Weighted mode	23	-0.0130155	0.0726776	0.8595094

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.67607	21	0.4788731
Inverse variance weighted	20.68503	22	0.5402702

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000534	0.0056423	0.9254899

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006568	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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