Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 457)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0490533	0.1225857	0.6930836
Weighted median	23	0.0827861	0.0550536	0.1326494
Inverse variance weighted	23	0.0731603	0.0468627	0.1184856
Simple mode	23	0.0843512	0.0865287	0.3402401
Weighted mode	23	0.0843512	0.0576053	0.1572573

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.67146	21	0.0631862
Inverse variance weighted	31.74030	22	0.0819326

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014804	0.0069292	0.8328807

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010683	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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