Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 455)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0536183	0.1185173	0.6556132
Weighted median	23	-0.0468835	0.0544819	0.3894943
Inverse variance weighted	23	-0.0576919	0.0463665	0.2134048
Simple mode	23	-0.0771460	0.0980054	0.4395858
Weighted mode	23	-0.0322326	0.0667992	0.6341958

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.60382	21	0.1002430
Inverse variance weighted	31.07151	22	0.0946616

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0068355	0.0066991	0.3191712

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010077	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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