Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 454)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1224623	0.1175025	0.3091650
Weighted median	23	-0.1450322	0.0573822	0.0114885
Inverse variance weighted	23	-0.0737305	0.0450874	0.1019905
Simple mode	23	-0.1094368	0.0988883	0.2803909
Weighted mode	23	-0.1200201	0.0708222	0.1042492

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.09970	21	0.1116283
Inverse variance weighted	29.38102	22	0.1343007

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029926	0.0066418	0.6569156

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009985	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8