Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 453)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1195828	0.1061270	0.2725431
Weighted median	23	-0.0228715	0.0593223	0.6998325
Inverse variance weighted	23	-0.0097191	0.0417298	0.8158340
Simple mode	23	-0.0401436	0.1001596	0.6924358
Weighted mode	23	-0.0712691	0.0800665	0.3830303

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.73767	21	0.3059418
Inverse variance weighted	25.16747	22	0.2891332

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067467	0.0059988	0.2734173

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007645	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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