Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 452)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0287137	0.1430498	0.8428445
Weighted median	23	0.0697282	0.0618487	0.2595739
Inverse variance weighted	23	-0.0033727	0.0547042	0.9508390
Simple mode	23	0.0937815	0.1179278	0.4349676
Weighted mode	23	0.0708533	0.0806183	0.3889689

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.12993	21	0.0030256
Inverse variance weighted	43.25190	22	0.0043933

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019704	0.0080858	0.8098373

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013108	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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