Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 451)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1698876	0.0998195	0.1035249
Weighted median	23	0.0833580	0.0552343	0.1312550
Inverse variance weighted	23	0.0861626	0.0390152	0.0272139
Simple mode	23	0.0573761	0.1013955	0.5772127
Weighted mode	23	0.0740153	0.0748246	0.3333283

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.65125	21	0.6709543
Inverse variance weighted	18.48163	22	0.6770810

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0051416	0.0056423	0.3725043

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007078	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis