Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 450)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0301105	0.1132659	0.7929558
Weighted median	23	-0.0256614	0.0579591	0.6579465
Inverse variance weighted	23	-0.0088436	0.0432959	0.8381499
Simple mode	23	0.0591786	0.0884548	0.5104389
Weighted mode	23	-0.0013017	0.0701617	0.9853647

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.03872	21	0.1695751
Inverse variance weighted	27.09230	22	0.2077418

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001306	0.0064023	0.8403273

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008225	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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