Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 45)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0518697	0.1162365	0.6599894
Weighted median	23	0.0125094	0.0556374	0.8221054
Inverse variance weighted	23	-0.0153416	0.0445101	0.7303372
Simple mode	23	0.0546230	0.0920745	0.5590653
Weighted mode	23	0.0176529	0.0604663	0.7730628

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.47476	21	0.1271930
Inverse variance weighted	28.63282	22	0.1556456

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022432	0.0065702	0.7361836

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008723	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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