Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 449)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0356122	0.0998208	0.7248306
Weighted median	23	0.0337997	0.0557844	0.5445821
Inverse variance weighted	23	-0.0034973	0.0390159	0.9285743
Simple mode	23	0.0497078	0.0901034	0.5867314
Weighted mode	23	0.0415383	0.0607113	0.5009974

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.70357	21	0.6041491
Inverse variance weighted	18.82574	22	0.6560628

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019722	0.0056423	0.7301724

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005707	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8