Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 448)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0998609	0.0998206	0.3285041
Weighted median	23	-0.0134303	0.0578723	0.8164856
Inverse variance weighted	23	-0.0467140	0.0390157	0.2311850
Simple mode	23	-0.0974614	0.0973219	0.3275058
Weighted mode	23	0.0247534	0.0770553	0.7510586

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.51444	21	0.9246781
Inverse variance weighted	15.05938	22	0.8596773

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0090012	0.0056423	0.1255885

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004998	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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