Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 447)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2846281	0.0998193	0.0095580
Weighted median	23	0.1038791	0.0585435	0.0759985
Inverse variance weighted	23	0.0388212	0.0426774	0.3630108
Simple mode	23	0.0511134	0.1131527	0.6558922
Weighted mode	23	0.1157493	0.0691940	0.1085247

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.16667	21	0.5744491
Inverse variance weighted	26.32412	22	0.2380266

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0150951	0.0056423	0.0141624

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008277	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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