Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 446)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0042331	0.0998207	0.9665746
Weighted median	23	-0.0517632	0.0542165	0.3397043
Inverse variance weighted	23	-0.0443141	0.0390157	0.2560399
Simple mode	23	0.0888699	0.0861396	0.3134234
Weighted mode	23	-0.0374372	0.0651467	0.5713511

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.43920	21	0.7444888
Inverse variance weighted	16.71838	22	0.7787071

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029813	0.0056423	0.6027781

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005457	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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