Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 445)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1434486	0.1080859	0.1987013
Weighted median	23	-0.0404102	0.0581359	0.4869933
Inverse variance weighted	23	-0.0312926	0.0425053	0.4616062
Simple mode	23	0.0059442	0.1066702	0.9560640
Weighted mode	23	-0.0445705	0.0715534	0.5397557

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.62179	21	0.2639160
Inverse variance weighted	26.11185	22	0.2469106

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068875	0.0061095	0.2723181

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008107	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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