Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 443)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0025911	0.0998196	0.9795358
Weighted median	23	0.0531661	0.0553695	0.3369512
Inverse variance weighted	23	0.0258483	0.0390153	0.5076394
Simple mode	23	0.0134307	0.1136518	0.9070021
Weighted mode	23	0.0736614	0.0666506	0.2810186

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.78908	21	0.5986686
Inverse variance weighted	18.85315	22	0.6543781

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014282	0.0056423	0.8026302

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005846	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8