Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 442)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0710368	0.1224045	0.5678580
Weighted median	23	-0.0090764	0.0600684	0.8798954
Inverse variance weighted	23	-0.0308249	0.0468848	0.5108855
Simple mode	23	-0.0738746	0.1176093	0.5363820
Weighted mode	23	-0.0059975	0.0709045	0.9333555

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.57839	21	0.0645561
Inverse variance weighted	31.76994	22	0.0814037

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024694	0.0069189	0.7247211

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009816	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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