Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 441)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0969297	0.1250571	0.4469308
Weighted median	23	-0.0263360	0.0668144	0.6934577
Inverse variance weighted	23	0.0365771	0.0492616	0.4577807
Simple mode	23	0.0007230	0.1307526	0.9956380
Weighted mode	23	-0.0547450	0.1170604	0.6446241

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.96247	21	0.0466349
Inverse variance weighted	35.07396	22	0.0380611

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081987	0.0070689	0.2591354

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010894	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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