Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 440)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0380650	0.0998192	0.7067825
Weighted median	23	-0.0486255	0.0553027	0.3792597
Inverse variance weighted	23	-0.0139556	0.0390153	0.7205706
Simple mode	23	-0.0149713	0.1057835	0.8887411
Weighted mode	23	-0.0118039	0.0762279	0.8783509

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.56625	21	0.4856909
Inverse variance weighted	20.63511	22	0.5433761

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014806	0.0056423	0.7955665

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006292	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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