Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 44)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2047495	0.0998195	0.0529303
Weighted median	23	0.0145194	0.0563678	0.7967282
Inverse variance weighted	23	-0.0034141	0.0390155	0.9302699
Simple mode	23	0.0002129	0.0963451	0.9982565
Weighted mode	23	0.0079334	0.0717355	0.9129425

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.76201	21	0.8347016
Inverse variance weighted	19.56386	22	0.6103004

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0123641	0.0056423	0.0398453

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005931	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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