Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 439)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0859027	0.0998207	0.3991940
Weighted median	23	0.0523905	0.0543208	0.3348130
Inverse variance weighted	23	0.0229273	0.0390159	0.5567740
Simple mode	23	-0.0971929	0.1007947	0.3453934
Weighted mode	23	0.0482614	0.0680988	0.4859550

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.88425	21	0.9426900
Inverse variance weighted	12.35404	22	0.9496302

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038673	0.0056423	0.5005826

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003848	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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