Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 438)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1205698	0.1086828	0.2798121
Weighted median	23	-0.0576216	0.0580188	0.3206353
Inverse variance weighted	23	-0.0597246	0.0418669	0.1537137
Simple mode	23	-0.1175011	0.1002423	0.2536657
Weighted mode	23	-0.0613802	0.0693733	0.3858429

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.89461	21	0.2517574
Inverse variance weighted	25.33316	22	0.2814096

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037365	0.0061433	0.54956

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008387	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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