Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 437)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1502072	0.1179017	0.2165816
Weighted median	23	0.0476211	0.0588331	0.4182701
Inverse variance weighted	23	0.0255214	0.0477513	0.5930197
Simple mode	23	0.0951271	0.0970993	0.3378913
Weighted mode	23	0.0581912	0.0658281	0.3862620

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.29685	21	0.1070552
Inverse variance weighted	32.95486	22	0.0625116

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0107915	0.0066644	0.1203086

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010115	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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