Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 436)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0455703	0.0998201	0.6526997
Weighted median	23	0.0282265	0.0568453	0.6195067
Inverse variance weighted	23	0.0071866	0.0390156	0.8538584
Simple mode	23	-0.0039753	0.0964015	0.9674790
Weighted mode	23	0.0278171	0.0655201	0.6752813

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.43820	21	0.4936770
Inverse variance weighted	20.61273	22	0.5447695

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023571	0.0056423	0.680362

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006256	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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