Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 435)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0332051	0.1271553	0.7965299
Weighted median	23	-0.0244599	0.0569591	0.6676107
Inverse variance weighted	23	0.0397052	0.0490034	0.4177951
Simple mode	23	0.0949806	0.1081885	0.3894753
Weighted mode	23	-0.0133834	0.0579754	0.8195676

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.07623	21	0.0355642
Inverse variance weighted	34.70593	22	0.0415737

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044774	0.0071874	0.5400244

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001083	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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