Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 434)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1148073	0.1183838	0.3431897
Weighted median	23	-0.0353244	0.0563289	0.5305874
Inverse variance weighted	23	-0.0030721	0.0463250	0.9471257
Simple mode	23	-0.1077982	0.1028905	0.3061522
Weighted mode	23	-0.0387119	0.0673986	0.5715428

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.53671	21	0.1017007
Inverse variance weighted	31.01560	22	0.0957968

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068616	0.0066916	0.3168386

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00094	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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