Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 433)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0737243	0.0998206	0.4683445
Weighted median	23	0.0161924	0.0588557	0.7832235
Inverse variance weighted	23	0.0257208	0.0390157	0.5097395
Simple mode	23	-0.0744998	0.1037636	0.4803272
Weighted mode	23	0.0626682	0.0699944	0.3803015

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.37192	21	0.5612948
Inverse variance weighted	19.64489	22	0.6052421

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029479	0.0056424	0.6068198

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006085	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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