Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 432)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2147233	0.0998203	0.0432633
Weighted median	23	0.0812548	0.0563116	0.1490350
Inverse variance weighted	23	0.0362306	0.0394254	0.3581136
Simple mode	23	0.0448449	0.0904802	0.6250687
Weighted mode	23	0.0720275	0.0593803	0.2379995

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.6906	21	0.6049803
Inverse variance weighted	22.4646	22	0.4324680

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0109612	0.0056423	0.065584

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007069	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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