Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 431)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0444607	0.1090805	0.6876960
Weighted median	23	-0.0221964	0.0572458	0.6982089
Inverse variance weighted	23	-0.0361052	0.0422885	0.3932257
Simple mode	23	-0.0759619	0.0846819	0.3794165
Weighted mode	23	-0.0193404	0.0605211	0.7523134

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.07686	21	0.2438505
Inverse variance weighted	25.84574	22	0.2583639

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049475	0.0061657	0.4312962

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008091	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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