Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 430)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1661270	0.1166519	0.1691007
Weighted median	23	-0.0644456	0.0552612	0.2435337
Inverse variance weighted	23	-0.0410643	0.0459624	0.3716248
Simple mode	23	-0.0226897	0.0886017	0.8002638
Weighted mode	23	-0.0645755	0.0639312	0.3234388

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.67936	21	0.1219146
Inverse variance weighted	30.53213	22	0.1060941

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076801	0.0065937	0.257179

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009587	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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