Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 43)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1465801	0.1029809	0.1693165
Weighted median	23	-0.0358745	0.0522647	0.4924604
Inverse variance weighted	23	-0.0151376	0.0410866	0.7125522
Simple mode	23	-0.0164882	0.0818501	0.8422030
Weighted mode	23	-0.0235004	0.0638361	0.7162894

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.35092	21	0.3795352
Inverse variance weighted	24.39753	22	0.3267422

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080718	0.0058209	0.1800826

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007438	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8