Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 429)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0662264	0.0998197	0.5142536
Weighted median	23	0.0413970	0.0539073	0.4425296
Inverse variance weighted	23	0.0346407	0.0390156	0.3746110
Simple mode	23	0.0019874	0.0915921	0.9828839
Weighted mode	23	0.0296765	0.0771085	0.7040321

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.68897	21	0.6050845
Inverse variance weighted	18.80715	22	0.6572046

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019397	0.0056423	0.7344336

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005938	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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