Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 428)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0040193	0.0998206	0.9682618
Weighted median	23	-0.0000675	0.0586076	0.9990815
Inverse variance weighted	23	-0.0221370	0.0390157	0.5704516
Simple mode	23	-0.0189943	0.0891141	0.8331763
Weighted mode	23	0.0012177	0.0686866	0.9860156

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.14752	21	0.9033688
Inverse variance weighted	13.22857	22	0.9265900

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016063	0.0056423	0.7786783

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004106	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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