Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 427)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0618558	0.0999669	0.5427270
Weighted median	23	-0.0107362	0.0557116	0.8471861
Inverse variance weighted	23	0.0255995	0.0390158	0.5117395
Simple mode	23	0.0264462	0.0907231	0.7733964
Weighted mode	23	-0.0017816	0.0593641	0.9763290

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.06147	21	0.4551958
Inverse variance weighted	21.96747	22	0.4618320

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053706	0.0056506	0.3526951

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006787	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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