Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 426)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0042177	0.1141511	0.9708749
Weighted median	23	-0.0016255	0.0554299	0.9766051
Inverse variance weighted	23	-0.0503101	0.0438697	0.2514610
Simple mode	23	0.0165605	0.0920891	0.8589308
Weighted mode	23	0.0201150	0.0630231	0.7526098

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.46269	21	0.1560580
Inverse variance weighted	27.81490	22	0.1818971

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033486	0.0064524	0.6092114

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008932	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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