Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 425)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0068329	0.0998208	0.9460736
Weighted median	23	-0.0186692	0.0579077	0.7471532
Inverse variance weighted	23	-0.0097552	0.0390158	0.8025630
Simple mode	23	-0.0954657	0.0983109	0.3420748
Weighted mode	23	-0.0006161	0.0683141	0.9928856

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.68521	21	0.6688288
Inverse variance weighted	17.71780	22	0.7225826

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010187	0.0056423	0.8584592

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005388	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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