Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 423)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0110883	0.0998201	0.9126052
Weighted median	23	-0.0033596	0.0562754	0.9523952
Inverse variance weighted	23	-0.0283968	0.0390155	0.4667149
Simple mode	23	0.0058856	0.0997918	0.9535017
Weighted mode	23	-0.0013930	0.0744138	0.9852333

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.58114	21	0.8433675
Inverse variance weighted	14.76583	22	0.8720899

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024248	0.0056423	0.6717554

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004635	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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