Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 421)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0749799	0.0998203	0.4608984
Weighted median	23	0.0260518	0.0591006	0.6593548
Inverse variance weighted	23	0.0503481	0.0390156	0.1968906
Simple mode	23	0.1176051	0.1021211	0.2618380
Weighted mode	23	0.0571114	0.0695487	0.4203583

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.59975	21	0.5467243
Inverse variance weighted	19.67163	22	0.6035719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015126	0.0056423	0.7912475

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006466	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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