Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 420)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0767856	0.1192985	0.5267746
Weighted median	23	0.0373549	0.0644167	0.5619853
Inverse variance weighted	23	0.0161301	0.0463270	0.7277058
Simple mode	23	0.1246593	0.1051873	0.2486156
Weighted mode	23	0.0879540	0.0946251	0.3627179

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.99616	21	0.0920652
Inverse variance weighted	31.01887	22	0.0957301

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005706	0.0067433	0.4070015

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009451	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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