Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 42)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1056393	0.0998209	0.3019461
Weighted median	23	-0.0411873	0.0540219	0.4458103
Inverse variance weighted	23	-0.0311974	0.0390158	0.4239377
Simple mode	23	-0.0299342	0.0860300	0.7311845
Weighted mode	23	-0.0463485	0.0642488	0.4782657

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.75112	21	0.8800504
Inverse variance weighted	14.40755	22	0.8863855

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045715	0.0056423	0.4269082

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000456	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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