Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 419)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1958803	0.0998199	0.0631098
Weighted median	23	-0.0386854	0.0576397	0.5021191
Inverse variance weighted	23	-0.0518742	0.0390154	0.1836556
Simple mode	23	-0.0521442	0.1011628	0.6113811
Weighted mode	23	-0.0465477	0.0717892	0.5234408

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.00412	21	0.7694196
Inverse variance weighted	18.46067	22	0.6783524

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0088434	0.0056423	0.131981

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000613	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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