Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 418)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0370425	0.1075904	0.7340503
Weighted median	23	-0.0048848	0.0517766	0.9248362
Inverse variance weighted	23	-0.0332688	0.0415760	0.4235989
Simple mode	23	-0.0095347	0.0779149	0.9037142
Weighted mode	23	-0.0063093	0.0552882	0.9101803

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.39654	21	0.2742443
Inverse variance weighted	24.98216	22	0.2979289

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043178	0.0060815	0.4855212

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000779	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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