Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 417)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0200804	0.1428620	0.8895586
Weighted median	23	-0.0279280	0.0566734	0.6221620
Inverse variance weighted	23	0.0424868	0.0548485	0.4385631
Simple mode	23	-0.0281937	0.0874145	0.7500975
Weighted mode	23	-0.0326964	0.0624737	0.6059543

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.01529	21	0.0031293
Inverse variance weighted	43.47902	22	0.0041179

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038422	0.0080751	0.6391249

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001353	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8