Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 416)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0336373 0.1048050 0.7514197
Weighted median 23 0.0160199 0.0554508 0.7726555
Inverse variance weighted 23 -0.0160278 0.0402738 0.6906518
Simple mode 23 -0.0553224 0.1005131 0.5875904
Weighted mode 23 0.0277347 0.0685588 0.6897231

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.14965 21 0.3360517
Inverse variance weighted 23.44184 22 0.3771512

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0030499 0.0059241 0.6120448

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007155 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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