Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 415)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1400027	0.0998201	0.1753621
Weighted median	23	-0.0188792	0.0547723	0.7303303
Inverse variance weighted	23	-0.0467733	0.0390157	0.2305935
Simple mode	23	-0.0034326	0.0836557	0.9676404
Weighted mode	23	-0.0173588	0.0608222	0.7780058

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.43748	21	0.8500846
Inverse variance weighted	18.56991	22	0.6717148

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0114699	0.0056423	0.0549045

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006063	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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