Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 414)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1194355	0.0998201	0.2448330
Weighted median	23	0.0147834	0.0527283	0.7791936
Inverse variance weighted	23	0.0275939	0.0390154	0.4794065
Simple mode	23	-0.0272627	0.0889252	0.7620460
Weighted mode	23	0.0627358	0.0709446	0.3861006

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.52249	21	0.9244274
Inverse variance weighted	13.52166	22	0.9175840

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00564	0.0056423	0.3288901

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004249	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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