Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 413)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2153575	0.0998185	0.0427029
Weighted median	23	0.1133189	0.0580740	0.0510232
Inverse variance weighted	23	0.0752335	0.0390967	0.0543181
Simple mode	23	0.1002293	0.0961300	0.3084362
Weighted mode	23	0.1251426	0.0680155	0.0793135

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.76606	21	0.5361194
Inverse variance weighted	22.09202	22	0.4544075

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086051	0.0056423	0.1421516

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007821	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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